AXE 3 Vascular inflammation in the damaged retina

Many ocular diseases (glaucoma, diabetic retinopathy, aged related macular degeneration) are characterized by microcirculation alterations including blood flow dysfunction and vascular inflammation.

We are interested in the mechanisms of retinal damage that lead to blindness, particularly the one related to the kallikrein-kinin system which  play a significant role in vascular inflammation.

We have already shown that topic administration of a kinin receptor antagonist prevents the majority of the pathological features.

We have also developed an autoradiographic method as well as laser Doppler flowmetry to measure blood flow in the retina. 

The model is used for the studies of the involvement of the ocular blood flow in the time course of ocular disease such as diabetic retinopathy and glaucoma.